تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Free fatty acids (FFAs) – induced PKC and NFB activation, two key events in two different models for insulin resistance, the skeletal muscle and liver
Free fatty acids (FFAs) – induced PKC and NFB activation, two key events in two different models for insulin resistance, the skeletal muscle and liver
 
الموضوع : Free fatty acids (FFAs) – induced PKC and NFB activation, two key events in two different models for insulin resistance, the skeletal muscle and liver 
لغة الوثيقة : الانجليزية 
المستخلص : We examined the effects of FFAs on insulin signaling in both muscle and liver. In the muscle, the glucose uptake showed a 50% increase over basal in control cells treated with insulin. However, cells treated with either oleate or palmitate showed a statistically significant reduction in insulin stimulated glucose uptake (p<0.05). The PKB was reduced by 26% in cells treated with oleate and > 50% (p<0.05) reduction in cells treated with palmitate. The oleate treated myocytes showed a significant increase in the phosphorylation of PKC alpha, beta, delta and epsilon isoforms. PKC inhibition with Bis-I (2 mM) was capable of reversing the oleate induced insulin resistance in myocytes by improving the glucose uptake and the PKB phosphorylation status. FFA treatment in myocytes led to the activation of NFkB as shown from the expression of IKK in the kinases screen. In contrast there was no significant changes in cultured primary hamster hepatocytes for the insulin receptor tyrosine phosphorylation or mass even in the presence of high insulin. The Phosphosite showed an increased phosphorylation of PKC- related kinase 1 and 2 with the activation of the Ras-MAPK pathway and a reduction in the expression level of IB in the fructose fed hamster. The data show a direct desensitization of muscle cells following FFA exposure but no observable changes in hepatic insulin signaling, suggesting that FFA-induced insulin resistance is exerted through different mechanisms. And it points out the importance of PKC and NFB activation following direct treatment with FFA in the two models. 
ردمد : 0 
اسم الدورية : Journal of Diabetes and Vascular Disease Research 
المجلد : 3 
العدد : 2 
سنة النشر : 2006 هـ
1427 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, June 15, 2009 

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اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
أمينةAminaباحث رئيسيدكتوراه 
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