تفاصيل الوثيقة
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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Synthesis and antiinflammatory evaluation of some more new 1,2,4-triazolo[3,4-b] thiadiazoles as an antimicrobial agent: Part-I Synthesis and antiinflammatory evaluation of some more new 1,2,4-triazolo[3,4-b] thiadiazoles as an antimicrobial agent: Part-I |
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الموضوع |
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كيمياء |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Some of the new 1,2,4-triazolothiadiazole derivatives (2-9) have been synthesized starting from the interaction between 4-amino-3-(pyrid-4yl)-5- mercapto-1,2,4-triazole(1) and α, α,β,-bifunctional compounds, such as tri ethylphosphite, trifluroacetamide, cyanamide, isolthiocyante, carbon disulfide and /or fluorinated aromatic aldehydes in different conditions. The new semi-drugs 5-substituted amino-4-amino-3-(pyrid-4y)1,2,4-triazoles(10a,10b) were also obtained from treatment of compound1 with 4-fluoroanline and sulfa-drug as sulfathiazole. Structure of the products have been established on the basis of their elemental analysis and spectral (UV, IR, 1HNAR, 13Cnmr and mass) data. The novel molecules synthesized were evaluated for their anti-inflammatory and antimicrobial behavior in comparison with Indomethacin (Anti-inflammatory), Nalidexic acid (bacteria) and Nystain (fungi) as antibiotics, Where the compounds 3,7b and 9exhibited higher activities. |
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ردمد |
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0974-4290 |
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اسم الدورية |
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International Journal of ChemTech Research |
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المجلد |
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3 |
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العدد |
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1 |
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سنة النشر |
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1432 هـ
2011 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Saturday, June 16, 2012 |
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الباحثون
| رضا محمدي عبدالرحمن | Abdel-Rahman, Reda Mohammady | باحث | دكتوراه | r-mrahman1951@yahoo.com |
| خالد عمر الفوتي | Al-Footy, Khalid Omar | باحث | دكتوراه | kalfooti@kau.edu.sa |
| F M Aqlan | Aqlan, F M | باحث | دكتوراه | |
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الرجوع إلى صفحة الأبحاث
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