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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
RASSF2 methylation is a strong prognostic marker in younger age patients with Ewing sarcoma
RASSF2 methylation is a strong prognostic marker in younger age patients with Ewing sarcoma
 
لغة الوثيقة : الانجليزية 
المستخلص : Ras-association domain family of genes consist of 10 members (RASSF1-RASSF10), all containing a Ras-association (RA) domain in either the C- or the N-terminus. Several members of this gene family are frequently methylated in common sporadic cancers; however, the role of the RASSF gene family in rare types of cancers, such as bone cancer, has remained largely uninvestigated. In this report, we investigated the methylation status of RASSF1A and RASSF2 in Ewing sarcoma (ES). Quantitative real-time methylation analysis (MethyLight) demonstrated that both genes were frequently methylated in Ewing sarcoma tumors (52.5% and 42.5%, respectively) as well as in ES cell lines and gene expression was upregulated in methylated cell lines after treatment with 5-aza-2'-deoxcytidine. Overexpression of either RASSF1A or RASSF2 reduced colony formation ability of ES cells. RASSF2 methylation correlated with poor overall survival (p = 0.028) and this association was more pronounced in patients under the age of 18 y (p = 0.002). These results suggest that both RASSF1A and RASSF2 are novel epigenetically inactivated tumor suppressor genes in Ewing sarcoma and RASSF2 methylation may have prognostic implications for ES patients. 
ردمد : 1559-2294 
اسم الدورية : Epigenetics 
المجلد : 8 
العدد : 9 
سنة النشر : 1434 هـ
2013 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Wednesday, April 6, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Seley GharaneiGharanei, Seley باحث رئيسي  
Anna T BriniBrini, Anna T باحث مشارك  
Sumathi VaiyapuriVaiyapuri, Sumathi باحث مشارك  
Abdullah AlholleAlholle, Abdullah باحث مشارك  
Ashraf DallolDallol, Ashraf باحث مشارك  
Elena ArrigoniArrigoni, Elena باحث مشارك  
Takeshi KishidaKishida, Takeshi باحث مشارك  

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