تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Comparative Analysis of Syntenic Genes in Grass Genomes Reveals Accelerated Rates of Gene Structure and Coding Sequence Evolution in Polyploid Wheat
Comparative Analysis of Syntenic Genes in Grass Genomes Reveals Accelerated Rates of Gene Structure and Coding Sequence Evolution in Polyploid Wheat
 
لغة الوثيقة : الانجليزية 
المستخلص : Cycles of whole-genome duplication (WGD) and diploidization are hallmarks of eukaryotic genome evolution and speciation. Polyploid wheat (Triticum aestivum) has had a massive increase in genome size largely due to recent WGDs. How these processes may impact the dynamics of gene evolution was studied by comparing the patterns of gene structure changes, alternative splicing (AS), and codon substitution rates among wheat and model grass genomes. In orthologous gene sets, significantly more acquired and lost exonic sequences were detected in wheat than in model grasses. In wheat, 35% of these gene structure rearrangements resulted in frame-shift mutations and premature termination codons. An increased codon mutation rate in the wheat lineage compared with Brachypodium distachyon was found for 17% of orthologs. The discovery of premature termination codons in 38% of expressed genes was consistent with ongoing pseudogenization of the wheat genome. The rates of AS within the individual wheat subgenomes (21%-25%) were similar to diploid plants. However, we uncovered a high level of AS pattern divergence between the duplicated homeologous copies of genes. Our results are consistent with the accelerated accumulation of AS isoforms, nonsynonymous mutations, and gene structure rearrangements in the wheat lineage, likely due to genetic redundancy created by WGDs. Whereas these processes mostly contribute to the degeneration of a duplicated genome and its diploidization, they have the potential to facilitate the origin of new functional variations, which, upon selection in the evolutionary lineage, may play an important role in the origin of novel traits. 
ردمد : 0032-0889 
اسم الدورية : PLANT PHYSIOLOGY 
المجلد : 161 
العدد : 1 
سنة النشر : 1434 هـ
2013 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, July 25, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Eduard AkhunovAkhunov, Eduard باحث  
Sunish SehgalSehgal, Sunish باحث  
Hanquan LiangLiang, Hanquan باحث  
Shichen WangWang, Shichen باحث  
Alina AkhunovaAkhunova, Alina باحث  
Gaganpreet KaurKaur, Gaganpreet باحث  
Wanlong LiLi, Wanlong باحث  
Kerrie ForrestForrest, Kerrie باحث  
Deven SeeSee, Deven باحث  
Hanaa SimkovaSimkova, Hana باحث  
Yaqin MaMa, Yaqin باحث  
Matthew HaydenHayden, Matthew باحث  
Mingcheng LuoLuo, Mingcheng باحث  
Justin FarisFaris, Justin باحث  
Jaroslav DolezelDolezel, Jaroslav باحث  
Bikram GillGill, Bikram باحث  

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