تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Fish Oil Supplementation Decreases Oxidative Stress but Does Not Affect Platelet-Activating Factor Bioactivity in Lungs of Asthmatic Rats
Fish Oil Supplementation Decreases Oxidative Stress but Does Not Affect Platelet-Activating Factor Bioactivity in Lungs of Asthmatic Rats
 
لغة الوثيقة : الانجليزية 
المستخلص : Dietary fish oil supplementation increases the content of n-3 polyunsaturated fatty acids (PUFA) in cellular membranes. The highly unsaturated nature of n-3 PUFA could result in an enhanced lipid peroxidation in the oxidative environment characteristic of asthma. The oxidative reaction cascade culminates in an increased production of components associated to oxidative stress and of an important proinflammatory mediator platelet-activating factor (PAF)-like lipid. We evaluated the effect of fish oil supplementation in asthmatic rats upon the PAF bioactivity and parameters related to oxidative stress in the lung. Fish oil supplementation of asthmatic rats resulted in lower concentrations of nitrite (1.719 +/- A 0.137 vs. 2.454 +/- A 0.163 nmol/mL) and lipid hydroperoxide (72.190 +/- A 7.327 vs. 120.200 +/- A 11.270 nmol/mg protein). In asthmatic animals, fish oil increased the activities of superoxide dismutase (EC 1.15.1.1) (33.910 +/- A 2.325 vs. 24.110 +/- A 0.618 U/mg protein) and glutathione peroxidase (EC 1.11.1.9) (164.100 +/- A 31.250 vs. 12.590 +/- A 5.234 U/mg protein). However, fish oil did not affect PAF bioactivity in lung tissue of asthmatic rats (0.545 +/- A 0.098 340/380 vs. 0.669 +/- A 0.101 340/380 nm ratio). Considering the two-step process-oxidative stress and PAF bioactivity-fish oil exhibited a divergent action on these aspects of asthmatic inflammation, since the supplement lowered oxidative stress in the lungs of asthmatic rats, presenting an antioxidant effect, but did not affect PAF bioactivity. This suggests a dual effect of fish oil on oxidative stress and inflammation in asthma. 
ردمد : 0024-4201 
اسم الدورية : LIPIDS 
المجلد : 49 
العدد : 7 
سنة النشر : 1435 هـ
2014 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, August 7, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
A ZanattaZanatta, A باحث  
D MirandaMiranda, D باحث  
B DiasDias, B باحث  
R CamposCampos, R باحث  
M MassaroMassaro, M باحث  
P MichelottoMichelotto, P باحث  
A WestWest, A باحث  
E MilesMiles, E باحث  
P CalderCalder, P باحث  
A NishiyamaNishiyama, A باحث  

الملفات

اسم الملفالنوعالوصف
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