تفاصيل الوثيقة
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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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An integrated catalog of reference genes in the human gut microbiome An integrated catalog of reference genes in the human gut microbiome |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Many analyses of the human gut microbiome depend on a catalog of reference genes. Existing catalogs for the human gut microbiome are based on samples from single cohorts or on reference genomes or protein sequences, which limits coverage of global microbiome diversity. Here we combined 249 newly sequenced samples of the Metagenomics of the Human Intestinal Tract (MetaHit) project with 1,018 previously sequenced samples to create a cohort from three continents that is at least threefold larger than cohorts used for previous gene catalogs. From this we established the integrated gene catalog (IGC) comprising 9,879,896 genes. The catalog includes close-to-complete sets of genes for most gut microbes, which are also of considerably higher quality than in previous catalogs. Analyses of a group of samples from Chinese and Danish individuals using the catalog revealed country-specific gut microbial signatures. This expanded catalog should facilitate quantitative characterization of metagenomic, metatranscriptomic and metaproteomic data from the gut microbiome to understand its variation across populations in human health and disease. |
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ردمد |
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1087-0156 |
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اسم الدورية |
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NATURE BIOTECHNOLOGY |
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المجلد |
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32 |
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العدد |
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8 |
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سنة النشر |
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1435 هـ
2014 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Monday, August 14, 2017 |
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الباحثون
| Junhua Li | Li, Junhua | باحث | | |
| Huijue Jia | Jia, Huijue | باحث | | |
| Xianghang Cai | Cai, Xianghang | باحث | | |
| Huanzi Zhong | Zhong, Huanzi | باحث | | |
| Qiang Feng | Feng, Qiang | باحث | | |
| Shinichi Sunagawa | Sunagawa, Shinichi | باحث | | |
| Manimozhiyan Arumugam | Arumugam, Manimozhiyan | باحث | | |
| Jens Kultima | Kultima, Jens | باحث | | |
| Edi Prifti | Prifti, Edi | باحث | | |
| Trine Nielsen | Nielsen, Trine | باحث | | |
| Agnieszka Juncker | Juncker, Agnieszka | باحث | | |
| Chaysavanh Manichanh | Manichanh, Chaysavanh | باحث | | |
| Bing Chen | Chen, Bing | باحث | | |
| Wenwei Zhang | Zhang, Wenwei | باحث | | |
| Florence Levenez | Levenez, Florence | باحث | | |
| Juan Wang | Wang, Juan | باحث | | |
| Xun Xu | Xu, Xun | باحث | | |
| Liang Xiao | Xiao, Liang | باحث | | |
| Suisha Liang | Liang, Suisha | باحث | | |
| Dongya Zhang | Zhang, Dongya | باحث | | |
| Zhaoxi Zhang | Zhang, Zhaoxi | باحث | | |
| Weineng Chen | Chen, Weineng | باحث | | |
| Hailong Zhao | Zhao, Hailong | باحث | | |
| Jumana (Al-Aama | (Al-Aama, Jumana | باحث | | |
| Sherif Edris | Edris, Sherif | باحث | | |
| Huanming Yang | Yang, Huanming | باحث | | |
| Jian Wang | Wang, Jian | باحث | | |
| Torben Hansen | Hansen, Torben | باحث | | |
| Henrik Nielsen | Nielsen, Henrik | باحث | | |
| Soren Brunak | Brunak, Soren | باحث | | |
| Karsten Kristiansen | Kristiansen, Karsten | باحث | | |
| Francisco Guarner | Guarner, Francisco | باحث | | |
| Oluf Pedersen | Pedersen, Oluf | باحث | | |
| Joel Dore | Dore, Joel | باحث | | |
| S Ehrlich | Ehrlich, S | باحث | | |
| Peer Bork | Bork, Peer | باحث | | |
| Jun Wang | Wang, Jun | باحث | | |
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الرجوع إلى صفحة الأبحاث
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