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Haytham Ahmed Zakai
Document Details
Document Type
:
Article In Journal
Document Title
:
Effect of itraconazole and terbinafine of leishmania major lesions in BALB/c mice
تاثير عقاري اتراكونازول وتيربينافين على قرح الليشمانيا العظيمة في الفئران
Subject
:
Leishmania
Document Language
:
English
Abstract
:
The effects of two antifungal compounds, the azole itraconazole and the allylamine terbinafine, on Leishmania major infections in mice are reported. Sixty BALB/c mice were each inoculated subcutaneously with metacyclic promastigotes of L. major at the base of the tail. From 4 weeks post-inoculation, 40 of the mice were treated for 4 weeks (20 with itraconazole and 20 with terbinafine) and the rest were left untreated. Lesion sizes were estimated weekly for 10 weeks post-infection. Both drugs appeared effective in treating the cutaneous lesions but response to itraconazole was faster and, at the end of the experiment, the mean size of the lesions on the mice treated with itraconazole was smaller than that of the lesions on the terbinafine-treated mice.
ISSN
:
1364-8594
Journal Name
:
Annals of Tropical Medicine & Parasitology
Volume
:
94
Issue Number
:
1
Publishing Year
:
1421 AH
2000 AD
Article Type
:
Article
Added Date
:
Sunday, October 26, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
هيثم أحمد زكائي
Zakai, Haytham Ahmed
Investigator
Doctorate
hzakai@kau.edu.sa
سمير خضر زمو
Zimmo, Sameer Khedr
Researcher
Doctorate
Files
File Name
Type
Description
18289.pdf
pdf
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