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Document Details
Document Type
:
Article In Journal
Document Title
:
An Efficient Approach to the Synthesis of Highly Congested 9,10-Dihydrophenanthrene-2,4-dicarbonitriles and Their Biological Evaluation as Antimicrobial Agents
An Efficient Approach to the Synthesis of Highly Congested 9,10-Dihydrophenanthrene-2,4-dicarbonitriles and Their Biological Evaluation as Antimicrobial Agents
Document Language
:
English
Abstract
:
An efficient and novel method for the synthesis in moderate to good yield (72%-84%) of a series of 3-amino-1-substituted-9,10-dihydrophenanthrene-2,4-dicarbonitriles 1-5 via one-pot multi-component reactions of aldehydes, malononitrile, 1-tetralone and ammonium acetate has been delineated. Cyclocondensation attempts of aminocyanophenanthrene derivatives 1, 2, 4 and 5 with acetic anhydride in the presence of conc. H2SO4 failed and instead the diacetylamino derivatives 10-13 were obtained. All prepared compounds were structurally elucidated by various spectroscopic methods and X-ray crystallography. N,N-diacetylamino-derivatives of phenanthrene have shown good antimicrobial activity.
ISSN
:
1420-3049
Journal Name
:
MOLECULES
Volume
:
18
Issue Number
:
12
Publishing Year
:
1434 AH
2013 AD
Article Type
:
Article
Added Date
:
Sunday, July 16, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
H Faidallah
Faidallah, H
Researcher
K Al-Shaikh
Al-Shaikh, k
Researcher
T Sobahi
Sobahi, T
Researcher
K Khan
Khan, K
Researcher
A Asiri
Asiri, A
Researcher
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