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Document Details
Document Type
:
Article In Journal
Document Title
:
Effect of melittin on mice stomach
Effect of melittin on mice stomach
Document Language
:
English
Abstract
:
Melittin, the main bee venom component, has many positive biological effects and a relatively low toxicity in various cell types. However, there is no evidence of the effect of melittin on gastrointestinal cells. In the present study, we investigated the histological and immuonohistochemical effects of melittin on mice stomach. Adult male mice (Albino Swiss) were randomly divided into two groups (7 mice for each group): control group and melittin only treated group (10 and 40 mu g/kg). These mice were sacrificed, then samples from the stomach were collected and prepared for histopathological studies by using alcian blue stain and immuonohistochemical studies by using smooth muscle actin (SMA) antibody. Treatment with melittin alone do not cause any harmful effect on the stomach tissue where the microscopic examination of Alcian blue stained section showed the normal distribution of the mucous secreting cells of the stomach tissues. On other hand, no changes were observed on smooth muscle cells. This study demonstrated the safety of using melittin on gastrointestinal tissues if used in definite dose and for suitable duration, which offers an opportunity for its use as a treatment for many diseases of the gastrointestinal tract. (C) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.
ISSN
:
1319-562X
Journal Name
:
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
Volume
:
21
Issue Number
:
1
Publishing Year
:
1435 AH
2014 AD
Article Type
:
Article
Added Date
:
Thursday, August 10, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Osama Abu-Zinadah
Abu-Zinadah, Osama
Researcher
Tarek Rahmy
Rahmy, Tarek
Researcher
Abeer Alahmari
Alahmari, Abeer
Researcher
Faiza Abdu
Abdu, Faiza
Researcher
Files
File Name
Type
Description
42559.pdf
pdf
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